Eli5: Why do low dopamine levels affect movement in people with Parkinson’s Disease?

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Eli5: Why do low dopamine levels affect movement in people with Parkinson’s Disease?

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Dopamine, in specific parts of the brain, is responsible for facilitating wanted movements and inhibiting unwanted ones *indirectly*. Insufficient levels therefore cause movement disorders since the appropriate facilitation/inhibition pathways are compromised.

Think of it as a marionette with springs in the bars. The springs don’t do a great job of translating the movements of the puppeteer into the movement of the marionette. Instead, the resulting movement will be jerky since essentially random movements have been injected in.