How can a medication have a half-life of several hours, but take weeks to begin working? What do doctors mean when they say a medicine has to “build up”? Why would any such medicine need to be taken multiple times per day?

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How can a medication have a half-life of several hours, but take weeks to begin working? What do doctors mean when they say a medicine has to “build up”? Why would any such medicine need to be taken multiple times per day?

In: Biology

Imagine you had a bucket with a hole in it.

if you wanted to keep the water level the same but could only add water in discreet units (like a cup) you might figure out how many cups and how often to add the cups to minimize water level variance.

That’s how medicine dosage works but MUCH more complicated.

I like the bucket analogy.. it has to get to therapeutic levels in your body for desired outcome for treatment of whatever it is designed to do

Also your body upregulates and down regulates receptors trying to keep balance. Gotta overcome that.