How does Alzheimers disease affects the brain?

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How does Alzheimers disease affects the brain?

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Short answer: we don’t know.
Longer answer: we don’t know but plaques?

Brain degeneration disease like Alzheimer’s and maybe prion diseases are very poorly understood but in general the formation of abnormal brain physiology causes basic functions to become impossible. Eventually this progresses from memory loss to actual physical problems like breathing and swallowing.