At a highly abstract level, computer science is about what can be done with computation; information science is about with communication.
Computation consider what types of problems can be solved, and how efficiently you can solve them with algorithmic approaches. Informatics looks at interfaces (with humans/systems), organizations, networks, and making decisions with information.
In practical application, CS degrees i see focus on math & pure programming; whereas CIS degrees I’ve seen have some math/programming/IT and then include stuff like business analysis & health informatics.
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