Could human-synthesized chemicals like LSD or Methamphetamine theoretically also occur in nature or are there structures/properties/materials irreplaceable?

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Full disclosure I’m on a journey back from Meth addiction. I’ve just always found it interesting how people will smoke Marijuana or eat Mushrooms but will refuse to do a line of coke or a tab of Acid. The logic is always that some substances occur naturally and are therefore fine for human consumption.

But wouldn’t human-made compounds and chemicals also eventually occur in nature given enough time and the right environment? Or are these chemicals 100% unnatural?

In: Chemistry