There are several things determining where a plant will grow. In general the plant will grow upwards and towards the light no matter how it is currently. But the specifics depends on the plant. It would usually prefer to be planted the right side up.
I would suggest that if you try to root a cutting of a plant then it would also help to “plant” it in soil before you cut it so that the roots will be able to develop on the cutting while it is still attached to the mother plant.
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