Flonase is actually an intranasal steroid, while Zyrtec is a second generation antihistamine known as cetirizine. Typically with allergic reactions that are serious (like anaphylaxis due to peanuts or bee stings), diphenhydramine (Benadryl), is used in IV form among other medications. Diphenhydramine is a first generation antihistamine that works a little differently from second gens. First generation antihistamines cross the blood-brain barrier and can make you drowsy. Sometimes they’re used for motion sickness and sleep aids depending on the medication, as where second gen antihistamines are usually only used for seasonal allergies. As far as I know, poison ivy is treated with a topical steroid and antihistamines.
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