do we know how ribosomes “know” which amino acid goes with which codon?

Question

I’m guessing the codon+ribosome changes the affinity of the molecule to be more accepting of a specific trna/amino acid? Do we know how exactly that happens though? Is my understanding of how it works correct at all?

Like, I know that uua codes for leucine, but there must be chemical properties that make it so, right?

We can try explaining like I’m 15, not 5 lol.

In: Biology

Answer 1

tRNA has a sequence of nucleotides called the anticodon that complements the codon, with some wobble in the third position. Same way any nucleotides base pair.