When there is excess glucose in the blood, insulin promotes glucose uptake mainly by the liver, adipose, and skeletal tissues. When there is low glucose in the blood, glucagon promotes release of glucose into the bloodstream, which will then be used by the cells for energy (e.g. skeletal tissue). So, in this case, both insulin and glucagon will both lead to glucose uptake in the skeletal cell? Or does insulin promote storage of glucose within the skeletal cell, which then gets released into the bloodstream by glucagon, but re-enters the skeletal cell for energy consumption?? Tried searching online for references, but couldn’t find the answer. Your insights will be much appreciated!
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>So, in this case, both insulin and glucagon will both lead to glucose uptake in the skeletal cell?
No. Glucagon has nothing to do with glucose uptake in cells.
Glucagon has two primary actions:
1. Stimulate the breakdown of glycogen stores into glucose (glycogenolysis)
2. Stimulate the conversion of amino acids into glucose (gluconeogenesis)
It also downregulates how much glucose the liver itself uses.
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