Eli5: Coevolution?

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Did animals coevolve with different substance in order to gain neurological receptors for them? Hence us having opiate receptors, tetrahydrocannabinol receptors etc?

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Opioids are naturally produced by our body, hence why opioid receptors exist. the THC receptor usually binds proteins that are also naturally present in out brain, it just so happens that they also bind THC. It’s a mistake to assume that, just because we have a receptor in our body that binds a certain molecule, that’s its “purpose”.

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