Currently working on an oncology presentation. Our professor assigned us a chemotherapy and we have to do in-depth research on it (indications, mechanism of action, etc). The drug I was assigned specifically is used for FGFR2 fusions. I’ve scoured through Pubmed, BioMed, and various oncology journals and I cannot get a straight answer as to what an FGFR fusion even is. All I’m getting is that it can amplify FGFR signaling, leading to proliferation, which I understand. I just don’t want to get to my presentation and my professor ask what an FGFR fusion is and I have no idea how to respond
Hopefully someone here is knowledgeable on this! Thanks!
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Our cells work based on DNA that tells them how to make more cells. Gene fusion is when chunks of that DNA that got merged together somehow. Genes have weird names. One specific type of gene fusion, called FGFR2, causes cells to make more cells way too much. That’s what cancer is.
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