ELI5. Grapefruit juice and the effects on mental health medication?

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To me it’s interesting that grapefruit juice is listed as a “no no” while taking antidepressants/anti-anxiety medication.

I’ve looked into it and I still don’t understand. Can someone explain why you aren’t supposed to mix them? I’m only asking because I like a good Ruby Grapefruit White Claw once and a while…

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13 Answers

Anonymous 0 Comments

Eating grapefruit or drinking grapefruit juice can affect some medicines. In most cases, it increases the level of the medicine in your blood. This can increase the risk of side effects or alter the effect the medicine has.

If your usual diet includes grapefruit or grapefruit juice and you’ve been prescribed a medicine that’s affected by grapefruit, speak to your GP or pharmacist. Do not stop taking your medicine without advice.

Medicines affected by grapefruit
Statins
Statins are medicines that lower your cholesterol. Grapefruit or grapefruit juice affects some statins.

Do not drink grapefruit juice if you’re taking simvastatin. Grapefruit juice increases the level of simvastatin in your blood and makes side effects more likely.

Atorvastatin interacts with grapefruit juice if you drink large quantities (more than 1.2 litres daily), but an occasional glass is thought to be safe.

Currently, healthcare professionals advise it is safe to drink grapefruit juice and eat grapefruit if you’re taking other types of statins.

Calcium channel blockers
Calcium channel blockers are medicines that relax the muscles that make up the walls of your arteries. They’re used as part of the treatment of conditions such as high blood pressure (hypertension) and coronary heart disease.

Grapefruit juice interacts with some calcium channel blockers and increases the level of the medicine in your blood. If you’re taking any of the medicines below, seek advice from your pharmacist or doctor if you wish to include grapefruit or grapefruit juice in your diet.

amlodipine
felodipine
lacidipine
lercanidipine
nicardipine
nifedipine
nimodipine
verapamil
Grapefruit juice does not affect diltiazem.

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