ELI5. Grapefruit juice and the effects on mental health medication?

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To me it’s interesting that grapefruit juice is listed as a “no no” while taking antidepressants/anti-anxiety medication.

I’ve looked into it and I still don’t understand. Can someone explain why you aren’t supposed to mix them? I’m only asking because I like a good Ruby Grapefruit White Claw once and a while…

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13 Answers

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Anticoagulants are medicines that help to prevent blood clots. They’re given to people at high risk of getting clots, to reduce their chances of serious conditions such as strokes and heart attacks.

Do not drink grapefruit juice if you’re taking warfarin. It can increase the effect of warfarin on your blood, making you bleed more easily.

It’s safer to drink grapefruit juice if you’re taking the newer anticoagulants rivaroxaban, dabigatran, apixaban or edoxaban.

Antiplatelet medicines
Antiplatelet medicines prevent platelets (a type of blood cell) from sticking together and forming blood clots. They help to prevent heart attacks and strokes.

Do not drink grapefruit juice if you’re taking the antiplatelet medicine clopidogrel, as it may mean your medicine works less effectively.

If you’re taking ticagrelor, grapefruit may increase the effects of your medicine and make you bleed more easily.

You do not need to avoid grapefruit if you’re taking dipyridamole or low-dose aspirin.

Ciclosporin and immunosuppressants
Ciclosporin, sirolimus and tacrolimus are medicines that moderate your immune system (the body’s natural defence system).

If you’re taking any of these medicines, do not drink grapefruit juice without consulting your doctor.

Entocort
Entocort is a medicine that contains budesonide and is used to treat Crohn’s disease, a condition that affects the digestive system.

Do not eat grapefruit or drink grapefruit juice while you’re taking this medicine, as the level of budesonide in your blood will increase.

Cytotoxic medicines
Some medicines used in the treatment of cancers may interact with grapefruit juice. You should check with your doctor before drinking grapefruit juice.

Other medicines
This list is not exhaustive and there are a number of other drugs that may interact with grapefruit. The risk of experiencing the effect of a drug interaction as a result of grapefruit can vary a lot from person to person.

For more information check the patient information leaflet that comes with your medicine, or you can ask your pharmacist

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