eli5: How do antidepressant actually work?

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I always hear people say the monoamine hypothesis of depression is outdated, so what’s actually happening and why is their a delay in symptom reduction when starting? Brain changes are seen a few hours after first dose

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Anonymous 0 Comments

Nobody is 100% sure. Thats where we are – there are lots of hypotheses but when ketamine comes along and seems to work instantly whereas prozac takes weeks then all bets are off,

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