They do if you use them wrong. The estradiol builds up the uterine lining, and the progesterone analog keeps it from shedding. If you use progesterone-only pills, no problem. If you use the 28-day cycle packs that give you a period every month, no problem. If you use the packs that give you a period once every three months, no problem. If you use Nexplanon, hormonal IUD, or depo shots, those are progesterone only so no problem.
If you use a combination of estradiol and progesterone analog with a sufficiently high dose of estradiol, and you never take a break for a period, then the uterus lining does start to build up and cause problems. If you take estrogen-only pills, which no doctor will ever prescribe you for birth control, that also will cause problems. Such as break-through bleeding and increased endometrial cancer risk. And when the period finally does happen, it is a thoroughly unpleasant experience.
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