Well it really depends on the drug and what’s happening.
To be very basic, things like depressants (alcohol, heroin, fentanyl,etc.) usually cause your breathing and heart rate to get so low to the point where you eventually stop breathing, hence why people with alcohol poisoning or heroin overdose start to turn blue.
Stimulants (cocaine, crack, meth) can cause your heart rate to increase to the point that causes cardiac arrest, it can also cause things like seizures and high fever which can damage organs.
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