Eli5: How does chromatography work?

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* How does it separate a mixture ?
* Does it separate something to all of it’s core components?
* Can we use it to break down the core components to their core components?

In: Chemistry

2 Answers

Anonymous 0 Comments

Chromatography will seperate chemicals, not break the chemicals down into their individual molecules. It is not a chemical reaction. The concept is that as a solvent is passed along the substance in question, the solvent will “drag” the unknown with it some percentage of the distance or speed of the solvents total. The most basic way to see this is used is used in early chem labs. You can put drops of unknown solutions on a paper, gently roll the paper up and place it in a jar of a known solvent. The dots are not submerged in the solvent and as the solvent creeps up the paper it will drag with it the unknowns. If there are 2 unknowns in the same sample, and the solvent has ratios that differ to each of those unknowns they will move along the paper at different rates, thus seperating them and allowing further analysis.

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