We don’t know exactly what causes depression or suicidal thoughts, and it’s probably not a single issue or at all uniform across all people.
So, a drug that simulates a hormone could help one person feel better because their body doesn’t make enough of it, but another person might be perfectly fine with that one chemical but make too much of another chemical, the underlying problem isn’t addressed, and you’ve thrown another part of the brain out of whack.
Then there is the issue that people’s brains work differently. What might feel better for one person could feel worse for another. Maybe the depression numbed a certain pain, with the numbness lifted things get worse.
It could also just be that some drugs stimulate the part of your brain that generates suicidal thoughts.
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