Eli5: how does restless legs know to start at the end of the day when it’s bedtime. Why isn’t it all day?

Question

I can go all day symptom Free, but as soon as I’m in bed- boom. Restless legs. Hate it

In: Biology

Answer 1

This is an area of active research, but the theory is dopamine. Dopamine coordinates muscle movement (among other things), but it also decreases at the end of the day to help your brain wind down and prepare for sleeping. So…dopamine goes down and is imbalanced, hello restless limbs.