Eli5: How does Saline Solution work within the blood stream?

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Fellows,

I’m reading about donating blood, and they said that in large volume plasma donation, a replacement of saline is added to your blood stream to account for the large volume taken. I’m just wondering how it’s okay to just replace blood with Saline

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It’s to keep your blood pressure at a healthy level, not to replace the plasma you’ve donated. When you lose blood volume there’s just less water in the pipes so to speak. At a certain point, you lose so much blood that when your heart pumps, your blood doesn’t circulate enough. You may still have enough oxygen and other nutrients in your blood to get by, but there’s just not a high enough water pressure in the pipes to get it where it needs to go. Saline just adds some neutral bulk to your blood to keep things moving while your body replenishes the plasma you donated.

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