In true ELI5 fashion;
when we start to develop our body has a bunch of tiny little robots. These robots went to school for a very specific subject, and then given specific jobs regarding that subject to grow into whatever career they are given. They are good at their job and even have ‘kids’ that run the family business to fix minor issues, but in the end after we are born, those robots cannot change jobs and only know how to do that one thing, and we are not left with a high number of ‘unemployed’ robots to give the ol ‘you need to get a job’ speech. But, those ‘unemployed’ robots still do important task such as renewing things inside our body. The robots with specific jobs can do their jobs well, but if any major problems arise, they again, can only do their job so well in some cases.
Our liver and skin are basically the only organs we can regenerate quite well, and it makes sense too since the liver and skin can get taxed very easily, all your blood essentially filters and gets cleaned by your liver, and it would be pretty bad survival wise if you just never were able to regrow patches of skin. Other organs have a lot of trouble regenerating things, they can heal minor wounds, but even then they can struggle with that.
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