These are very good questions, and the answer is basically “it’s really complicated.” There’s an entire field of science (pharmacology) just devoted to studying this!
With **most** drugs, they display what’s called “first-order kinetics.” This is a very fancy way of saying that a certain *percent* of the drug in your blood gets taken out by your liver/kidneys per a certain amount of time, *regardless of what dose you took*.
For example, for a drug with a “half-life” of one hour, if you take 100mg, after one hour you will have 50mg in your blood. After two hours, you will have 25mg…and so on. If you start by taking 50mg, after one hour you will have 25 mg in your blood, and after two hours you will have 12.5 mg. So taking a higher dose will give you a stronger effect, but it might also make it last longer!
Most real drugs are a bit more complicated than this, but this is the general idea.
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