Eli5 : protein folding problem
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Since your question is so broad, here is the most correct answer; Hydrogen Bonding (attaction of hydrogen to electronegative portions of amino acids), Disulfide bridges (Some amino acids have a sulfur, these form bonds with other sulfurs on other amino acids), and Steric interaction (With the last 2, folds and bends exist, but some amino acids bond at angles meaning they naturally form an angle when they bond, and sometimes the superstructure prevents certain kinds of bonds)
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