ELi5: Rats seem to be the gold standard for behavioral lab experiments – why? Other than quantity, what makes rats good test subjects in relation to humans?

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ELi5: Rats seem to be the gold standard for behavioral lab experiments – why? Other than quantity, what makes rats good test subjects in relation to humans?

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Unfortunately, while they are very tractable test subjects and very smart and social animals, there is a lot of evidence that they aren’t ideal test environments for human health questions. Coming from a long time rodent researcher, many very promising drugs in rodents have failed to work as expected in human trials.

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