Assuming the blood types are incompatible (and not just different), your body’s immune system will treat the foreign blood as what it is: foreign. So it will attack it violently. If the foreign blood contained white blood cells, they might also attack your own blood. Which is not very good for your health.
Of note is that there are many more blood parameters to take into account to avoid adverse reactions. Blood type and rhesus are only the main ones.
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