Your blood cells has these little markers and so your body knows these markers are yours. These markers are the blood types. When a new marker blood enters(incompatible blood type) your body thinks its a foreign body and clots around it, think of this as an accident on highway. These clots block your blood highways (blood vessels) which means some parts of blood will not receive blood. Now blood is a delivery van for oxygen and when these body parts dont recieve blood they DIE. If a small part of your brain dies then YOU die.
I dont think it can be more simplified than this while telling the whole story.
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