Eli5: what is the difference between a generic drug to the original drug, and why do some doctors will swear by the original drug?

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Eli5: what is the difference between a generic drug to the original drug, and why do some doctors will swear by the original drug?

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There are also some drugs, animal products, really like hormones and insulin, where switching to generic or another brand is simply an unknown because the science is as yet not understood exactly how the drugs work once ingested. Drugs like Premarin and Armour Synthroid are not recommended to be replaced by pharmacists with a similar product by another manufacturer because it may not be as efficacious.

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