The few people who have visited the bottom of the Challenger deep did so in submarines. The submarine’s hull must be built very strong to withstand the immense pressure. Inside the submarine the pressure is the same as it is on the surface, so the submarines occupants are not affected by the high pressure (which would kill them).
The deepest that scuba divers have gone is around 300m – but diving at such depths is very dangerous and requires the use of specialized gas mixtures, as normal air becomes toxic at such pressures.
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