Not a doctor. I’d imagine it’s because your liver is incredibly good at dealing with toxins. Nearly all medicines are poisonous the only thing that separates them from medicinal purposes and poisons is dose. Inventing something that you take orally or intravenously that doesn’t get filtered out is incredibly hard. There are devices such as TENS machines that work externally using small amounts of electrical energy to ease pain via induction. Most often used in pregnancy where’s it’s undesirable to have anything in the bloodstream that could affect the baby. But even those require new batteries regularly.
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