ELi5: Why didn’t europeans die too upon contact with new civilization?

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It is widely known that upon contact with new civilization, the indigionous people can be wiped out because they are not immune to our sicknesses; wouldn’t they also have some illness that europeans aren’t immune to?

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If a disease kills its host it also dies so germs evolve to not be too strong to kill the thing that they love in. Big animals like cows can handle stronger germs. When the germ jumps from cow to person it is too strong and kills the human. When Europeans domesticated cows, and other animals they lived in congested, dirty cities with those animals and the diseases kept jumping and killing the Europeans. Lots of Europeans died over 1000 years of domesticating various animals and getting sick with their various human killing diseases. If you read their history it is basically just going from one plague to the next. The only Europeans who survived had unusual immune systems that could fight the wired animal germs and they passed those unusual immune systems to their kids. Yay natural selection. Now the killer animal germs can live happily inside humans. When Europeans came to America they brought 1000 years worth of killer animal diseases with them. And those diseases hit all at once. Maybe an American had an unusual immune system that could withstand the black plague but not 10 other animal diseases also. They had no time to generationally evolve their immune systems to handle all these cow, pig, sheep germs.

On the other hand the Americans didn’t really domesticate animals so their “new to Europeans” germs were ones that could live in a normal human without killing it. Like syphilis.

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