Part of the reason was that the European cities at the time where real unsanitary, lots of intermingling btwn people and livestock, and higher population density than most other places, esp places colonised, made for real nice environments for infectious diseases.
Another part of the reason was while plenty of Europeans where going to live in the new colonies, the inhabitants of those places weren’t exactly invited to settle in Europe, so vectors of those new world diseases didn’t go to Europe as much as the other way around.
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