It is widely known that upon contact with new civilization, the indigionous people can be wiped out because they are not immune to our sicknesses; wouldn’t they also have some illness that europeans aren’t immune to?
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The shortest way to explain this is
Europeans squished together. So many people and animals meant more diseases. More diseases meant more immunities for only them. So when they traveled, they took ALL the diseases that they incubated with them to people with immune systems that no idea these diseases diseases existed.
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