It is widely known that upon contact with new civilization, the indigionous people can be wiped out because they are not immune to our sicknesses; wouldn’t they also have some illness that europeans aren’t immune to?
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To some extent it was luck. We now know bat viruses are very dangerous right out of the bat, no livestock needed. The New World has substantial bat populations. There could have been a nasty bat virus circulating in Mexico, but there wasn’t.
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