It is widely known that upon contact with new civilization, the indigionous people can be wiped out because they are not immune to our sicknesses; wouldn’t they also have some illness that europeans aren’t immune to?
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The tldr: the Americas didn’t have any animals to domesticate.
Europeans had a lot of animals to domesticate. Horses, cows, chickens, sheep, and so much more. But those most basic animals meant better farming capabilities. One person was able to produce enough food for many many more people, which meant more people were free to do other professions.
This leads it’s way into building major cities. People end up living close together, which means viruses have a huge concentrated masses of people to jump through. This means you end up with very potent viruses over time, although also a decently high herd immunity from infections. But you bring those viruses to another land where they don’t have those herd immunities and it’ll rip right through them.
On the flip side, the Americas didn’t have any animals that could be domesticated, so very little farming happened, so not many major cities formed. Viruses didn’t thrive, so no major diseases to pass the other way.
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