It is widely known that upon contact with new civilization, the indigionous people can be wiped out because they are not immune to our sicknesses; wouldn’t they also have some illness that europeans aren’t immune to?
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Outsiders come in with a whole bunch of infections and immunities from traveling around. There’s a good chance they’ll have something that the locals have not been exposed to yet if the locals haven’t been traveling around so much. This is the same thing that happened whenever ships would go to another country and then come back home bringing a new illness
If a ship full of explorers land and infect the native population the illness will spread through the native population killing a lot of them off quickly. It and fax the weakest in the group such as the young and the elderly. while they’re being taken care of as more opportunity to spread to the caretakers and everybody else.
If the explorers get infected, it could kill off the people on the ship quickly but doesn’t spread back to their homeland unless they’re able to make it back there before they die. The next ship to arrive has a smaller native population with reduced number of diseases to deal with.
Some diseases did go back to Europe. Syphilis was common in the Americas but wasn’t nearly as big of a deal to the natives there as it was to Europe. It became a terrible plague across Europe when it was brought back.
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