It is widely known that upon contact with new civilization, the indigionous people can be wiped out because they are not immune to our sicknesses; wouldn’t they also have some illness that europeans aren’t immune to?
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They definitely did, to some extent. The Haitian wars of independence are full of stories of European armies arriving, many of them immediately getting sick and the survivors getting defeated by Toussaint’s soldiers.
Edit: These were mostly deaths due to tropical diseases like dysentery and yellow fever, and were nowhere near as devastating as the plagues Europeans brought with them.
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