eli5: Why do antidepressant takes 2-4 weeks to work when brain changes happen right after the first dose?
In: Biology
Downstream effects where G proteins congregate in lipid rafts, in the brain, and cannot access cAMP, is the leading theory. Just because something binds to a receptor doesn’t always elicit a desired effect right away since further events must take place once the ligand is bound.
ELI5: binding to a receptor requires further steps in the cell to reach the desired effect and there is a problem with the second messenger system
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