Eli5: Why do certain antidepressants cause weight gain?

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Most people that i know seem to have gained weight on certain antidepressants, even when they’ve been eating the same and hitting the gym and claim to not be able to get rid of this weight no matter what they do.

What causes this? How do antidepressants change your metabolism?

In: Biology

7 Answers

Anonymous 0 Comments

Personally, I was told that I had developed insulin resistance as a result of my use of Effexor. Sugar doesn’t just turn into body fat on its own, it’s targeted by insulin which increases weight. My body was sending 3x as much insulin as necessary to deal with any given sugars, and a doctor told me that it was because of anti-depressants. When I halved my antidepressant I lost 40 lbs in 6 months.

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