ELI5- why do medications cause weight gain?

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I know with weight loss as a side effect it’s often due to decreased appetite and eating less. Does it cause the opposite with the side effect weight gain? You become more hungry?

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Anonymous 0 Comments

It’s complicated because medications can have many different effects, here are some examples

1) They make you store water, so you pee less than you drink, and you get heavier that way. This often makes you look puffy, a great example is how Putin currently looks, not to get topical, but it’s a good example for reference. His face used to be tight and angular and now he’s getting what they call a “moon face”, puffiness from water retention.

2) You reduce your metabolism, so you burn fewer calories than you used to and if you eat the same amount, well, you’ll gain wait.

3) They affect your “reward” center. A big part of modern eating is pleasure. You eat a cupcake and your brain rewards you with a rush of pleasurable chemicals. If a medication reduces the production of those chemicals, or your ability to sense them, you might now eat a second cupcake to get the same pleasure. So the medication be linked to overeating.

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