When medications are tested on a sample size of individuals before FDA approval etc, the participants are required to list any and all ill effects they experience while on the medication, even if they are being caused by something completely different.
This is why most medications have completely wacky side effects listed that have nothing to do with their actual mechanism of action. Depression as a side effect could very well just be “well, I’m still feeling as bad as I did before the medication, so nothing has changed.”
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