ELIF: why can’t AB+ people accept plasma from other blood types?

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I know it has to do with antibodies present in other types. However, if AB+ people can accept whole blood, which contains plasma, from any other blood type, why can’t they accept isolated plasma from any blood type? Wouldn’t the antibodies in the whole blood work the same as those in the plasma by itself?

In: Biology

3 Answers

Anonymous 0 Comments

I have never heard of this, I doubt it’s correct. Do you have a source I can review? AB+ can practically accept from anyone. Isolated plasma is just blood without blood cells, but has antibodies and proteins just the same.

Anonymous 0 Comments

Plasma from a B+ person may have antibodies against A

Plasma from O- may have antibodies against A, B and +

Anonymous 0 Comments

I don’t think it’s true that AB+ people can accept whole blood from any donor. They can accept red blood cells from any donor, but not plasma, and whole blood obviously contains both of those.

AB+ are universal acceptors of red blood cells (because their RBCs don’t express any antigens that people with other ABO/Rh blood types would attack) and universal donors of plasma (because their plasma doesn’t contain any antibodies for other ABO/Rh antigens).