Most of the connections formed are in the prefrontal cortex which governs, most importantly, impulse control. So if you do something to prevent it from growing properly you get stuck with the impulse control of a teenager.
So for instance you know that alcoholic or pothead you know that’s been using since 14 and it “never hurt them any” but they can’t seem to pay rent consistently or hold down a job for more than six months and they just swear it’s because they have bad luck and/or the whole world is against them?
It hurt them alright.
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