Yes, depending on the amount of muscle that is lost, humans would need less food. It pretty much comes down to gender, bodyweight and other factors, like reduced mobility. If someone loses their legs, they’d also become wheelchair bound, they would probably also move around less in general (not necessarily, I’ve known a person who lost his legs in a motorcycle accident who worked out a lot to maintain a very fit upper body) and therefore need less food as well. But yes, it could be a pretty significant difference in caloric intake.
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