Gene Editing


How are genes edited and what is CAS 9

In: 3

CAS9 is like “DNA scissors” and in essence allows for “cut and paste” operations on DNA.

We can use this to edit DNA in a batch of stem cells harvested from a patient, edit a fixed DNA sequence in, and then put the stem cells back into the patient bearing the new DNA sequence

Not only in human patients, but more commonly used in plants and microorganisms. Usually CRISPR/CAS is used to edit the DNA to add or alter certain genes to change the output of certain proteins etc.

You also can’t just randomly change any sequence within the DNA, you CRISPR/Cas always needs a certain succession of „letters“ – like a postman needs an address to deliver the package to the right person.

? Genes can be edited using a technology called CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats). CRISPR is a gene editing technology that uses a specialized enzyme called Cas9 (CRISPR-associated protein 9) to target and cut specific parts of the DNA sequence. Cas9 is a protein that binds to a short strand of RNA (guide RNA) that is programmed to recognize a specific sequence of DNA. The Cas9 enzyme then cuts the DNA at the targeted location, allowing scientists to insert, delete, or modify specific genes.