How and when did humans discover there was no air in space?

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How and when did humans discover there was no air in space?

In: 1574

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1643 Torricelli ~~indebted~~ (typo!) invented the barometer (to measure air pressure)

1648 Perier (prompted by his brother in law, Pascal) climbed Mount Puy de Dome with a barometer. Noticed that atmospheric pressure decreased with altitude

1659 von Guericke experimented with the vacuum pump. He concluded that the atmosphere was around the earth in a shell, getting less dense with altitude, and so it must reach a vacuum at some point

1687 Newton put forward his theory of Universal Gravitation

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