my current knowledge on sweeteners is that they are still very much controversial, because due to how they affect the gut microbiomes ad how they interact with them , it could be potentially more harmful and result in things like obesity despite having little to no calories. That said there is little known about it and most of them are indeed animal studies so conclusive evidence couldnt really be stated about it yet aside from that its probably not harmless(although minimal amount of them do suggest that they might be useful).
also like pacmain stated, there are also other things that do affect
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