The short answer is that new bacteria are appearing all the time because evolution happens on a generational scale. Bacteria reproduce geometrically, which allows them to go through several generations in the span of a few days, rather than a few centuries. Every generation, there will inevitably be a few bacteria with mutations in their genetic code. Enough of these mutations add up over the course of a few thousand generations, and boom – new bacteria. This happens anywhere bacteria are found, and bacteria are found on humans, which means bacteria will be found in the ISS.
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