Do they just use humans which are taking a risk? Even if theoretically something is safe and effective, you need to actually test it to verify.
In: Biology
It differs by manufacturer, but in general they will use chemicals or a mix that they know is safe on humans without the need to test it. They know this because the tests have already been done (on humans and animals) for cosmetics already in the market. A totally new chemical untested would need significant tests run before it was allowed to be sold in the market.
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