How can a $1 bet turn into $500,000 when so many football/basketball games are so lopsided?

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I’m talking specifically about [something like this](http://statsandshots.com/freaking-out-rn/) where there are 20 games picked. Couldn’t you just pick 20 games in the first few weeks of the college football season when all of the really good teams play really crappy schools? Same goes for something like college basketball. What’s the catch?

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