A cell mutates. Doesn’t do what it is supposed to do. This could result in the cell dying, or being unable to reproduce. If it does survive and reproduce, its children will also not do what they are supposed to do.
After several generations, you have a lump of tissue that is hogging resources, but not doing its job. This is cancer.
Also why there is not a cure yet. The mutation could be one of millions of different things that causes the cell to not function how it should.
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